The Alfred Centre is a purpose built, eight story healthcare building completed in 2010. Owned subject to a long-term ground lease (>25yrs remaining), the building comprises a mix of research, clinical, laboratory, educational, pathology, imaging, office and gymnasium uses. Major tenants include leading health research and educational institutions, including The Macfarlane Burnet Institute, La Trobe University, Monash University and Baker IDI Heart and Diabetes Institute. Highly specialized PC2 and PC3 laboratories for scientific research are also within the Alfred Centre. The adjoining Burnet Tower, also owned and managed by Northwest, provides synergies for key tenants Burnet Institute and Monash University.

The Alfred Centre is located 5 kilometres south of the Melbourne Central Business District, within the renowned Alfred Health Precinct. The precinct is built around The Alfred Hospital, a leading tertiary teaching hospital and the second oldest in Melbourne, offering a total of 638 beds and a wide array of services and specialized medical procedures, including but not limited to an intensive care unit, an infectious diseases unit, a lung transplant unit, a hyperbaric unit, and a burns unit. The site is extremely well serviced by public transit with direct bus and tram services immediately surrounding the site and South Yarra Railway Station 1km north-west.